Posted by JaclinHyde on February 28, 2006, at 3:59:38
Just read a nice abstract on the use of Marplan that has me wistful for the days using this drug. I know I am on parnate and I know I am a million times better but Marplan is a great middle of the road MAOI. Had to switch due to a doctor going "hey, you are mildly bipolar!" Parnate is the only MAOI that doesn't cause mania (right, that is why I am typing this at 4 a.m., LOL!) Ah hell, for what it is worth here is the abstract...
"An efficacy study of isocarboxazid and placebo in depression, and its relationship to depressive nosology
by
Davidson JR, Giller EL, Zisook S, Overall JE
Department of Psychiatry, Veterans Administration
Medical Center, Durham, NC 27705.
Arch Gen Psychiatry 1988 Feb; 45(2):120-7ABSTRACT
Isocarboxazid and placebo were evaluated in 130 anxious depressives. Drug was superior to placebo on depression, anxiety, interpersonal sensitivity, and global measures, and on symptoms of hostility, anxiety, obsessiveness, and psychological-cognitive components of depression. There were no significant differences between treatment effects on psychomotor and typical vegetative symptoms. Isocarboxazid was more effective than placebo in major, but not in minor, depression. It was significantly more effective in depression classified as endogenous depression or melancholia by various diagnostic criteria. Drug was more effective than placebo in atypical depression with vegetative reversal and in Brief Psychiatric Rating Scale (BPRS)-derived profiles of anxious and hostile depression; there were no drug-placebo differences in atypical depression without vegetative reversal, or in BPRS retarded and agitated/excited depression. Interpersonal sensitivity emerged as an important drug-responsive dimension."::sniff:: pure poetry :-)
JH
poster:JaclinHyde
thread:614153
URL: http://www.dr-bob.org/babble/20060227/msgs/614153.html