Posted by yxibow on February 27, 2006, at 17:00:19
In reply to The Truth Do SSRI's and SSNRI's Work For Anyone?, posted by Phillipa on February 27, 2006, at 13:12:49
> Was talking to a Medical Resident. He said the SSRI's and SNRI's are all hype. They may work for a few but not for the majority. Please some good experiences I'm fed up. Thanks Phillipa/ Jan
Prozac, Paxil, and definately Luvox all worked for me in different situations. I wouldn't trust the word of one Medical Resident who doesn't have a clinical practice, honestly, Jan. There have been bad things, sure, that have happened -- primarily because some places give GPs reign over prescribing psychiatric medications when psychopharmacologists/psychiatrists should be prescribing with some years of history behind them.
The comment about psychosomatic reading into side effects is not to be taken as an insult -- if one is not ready to take a drug, the placebo effect can work positively or negatively as much as 1/3 of the time.
Cymbalta still continues to keep me from being too suicidal or at all at times, so I would say that has a positive effect -- it doesnt do as much for my OCD repetitive thinking when my metabolism gets roaring, but one can't have it all.
The "hype" about kids killing themselves is, in, my opinion... hype. Sure, medicines that have not been adequately tested under 16/18 should not be given to those individuals -- but one also has to realize that a number of them would have been unfortunately predestined to take their lives or go on shooting sprees in those specific situations and cases that are over played in the media -- they were not too medicated, they were probably undermedicated or improperly medicated by psychiatrists with not enough skills. I took Prozac at 18 with no problems.
The biggest thing is that people don't stick to a particular SSRI long enough. As soon as upset stomach hits (which nearly all but the most recent ones) (5HT3), they drop the pill. This is callous, but they prefer to have a better sex life over depression (and I know, that can be depressing in itself, but medication is just not perfect -- it never ever will be, not at this stage of the 21st century), and they drop it because of that. So a drug that is meant to slowly develop signs of improvement over 2, 4, 6-12 weeks, is cast by the wayside as "useless" and nobody gets the benefits.
And what do we have by now, 6.. 7 if you count Anafranil, I forget... SSRIs, plus Cymbalta, which in my opinion is infinately better than Effexor in terms of side effects, but some people can stand caffeine like drugs and for them Effexor would be a godsend. So, no one SSRI can be the "right one" for someone. They all have ... the sites escape me at the moment, but if you look at the Ki/binding values for different 5HT receptors, different profiles.. and Zoloft is different because it touches Dopamine slightly, and Anafranil of course is a TCA.
And yes, they poop out sometimes. All drugs have that potential. But you can play the merrygoround and try a different SSRI and maybe even go back to the same one later, after a "holiday."
Don't give up. And no, I don't speak as the be all to end all of SSRIs. There are good and bad... but they've helped by now (prozac 1988 I think).. 18 patient years * # prescribed people, to some degree or another, to get on with their lives and to live them more productively. And in most cases with few outward signs that they are ever on a medication. There are millions of silent people in your workplace who are probably on one or another.
my 2c
Jay
poster:yxibow
thread:613775
URL: http://www.dr-bob.org/babble/20060227/msgs/613862.html