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Re: Prozac - 100 mg or more

Posted by SLS on February 17, 2006, at 8:10:46

In reply to Re: Prozac - 100 mg or more, posted by blueberry on February 16, 2006, at 16:34:27

> I've heard of prozac doses as high as 180mg. I wonder though how prozac's mechanism changes, if at all, at high doses, because I think the serotonin reuptake pumps are already completely 100% blocked at around 60mg to 80mg.

Norepinephrine? It might be just as effective to add desipramine. Linkage can probably better answer this question. These drugs do so many different things.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9451727&query_hl=4&itool=pubmed_docsum

The other possibility is that it takes a high concentration of Prozac in the blood to reach certain target tissues in the brain.


- Scott

 

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