Posted by yxibow on February 7, 2006, at 2:19:34
In reply to Re: Brand name Klonopin, posted by RobertDavid on February 7, 2006, at 1:00:33
> > I've never taken brand name benzodiazepines of any form.
>
> Then how can you compare brand vs generic?It was more a statement that brand name benzodiazepines are not prescribed any more on any regular basis except perhaps for epilepsy where tolerance is of the utmost importance because they're simply way too cheap to produce generic, and work just as well.
>
> > Drugs basically can have a bioequivalency of 80% to 125% (1/80%). But it gets more complicated, with confidence values that basically render tablets nearly to 100%.
>
> You pointed out the variance which doesn't make me feel comfortable, but who quoted the confidence value?The scientists at the FDA -- you can go argue with the Orange Book :)
>
> > The problem isn't so much that the drugs differ, the active ingredients are there... the problem lies in how the drug is delivered. The "inactive ingredients". E.g. the following drug contains cellulose, magnesium stearate, lactose... FD&C color.... These may affect how a drug is absorbed in the body and each manufacturer may use a different set of them.
>
> Doesn't that mean effect could be different vs brand?Its possible. Its a matter of delivery system. I'm not disputing that someone sensitive enough could notice a difference.
>
> > Brand name Klonopin is completely outdated and a waste of money as is most brand name benzodiazepines. It also is a subtle drug and you will not feel a "kick" like some other benzodiazepines. If a doctor really believes, or if a patient really believes that the generic is not performing the same, then prescribe a slightly higher amount of the generic. The savings between brand name benzodiazepines and their original counterparts, some of which are now 46 years old, can be as much as 10 times the price.
>
> A doctor should perscribe a higher dose if he/she believes it's not performing as well? How would he/she know whether or not to perscribe a higher dose or lower dose especially when each maker of generic may be stronger, weaker or with different inactive ingreadiants?
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> I don't want to seem argumentative here and appreciate your impute, but many generics are made overseas. That concerns me.Actually many expensive brand name drugs are developed "overseas" by subsidiaries or contractors of large drug companies. They may or may not be produced in the US directly.
Abilify - aripiprazole - Otsuka Pharmaceutical Co., Ltd, Tokyo, Japan.
Copaxone - glatiramer acetate injection for MS. Teva Pharmaceuticals, Petach Tikva, Israel.
Ambien - zolpidem - Sanofi-Adventis, Paris, France
Ketek - telithromycin - Sanofi-Adventis, Paris, FranceMy source informing me was involved in many of the studies for using klonpin for SP, a savvy doctor/researcher not making any money selling brand who highly recomends brand of klonopin and experience treating patients with both brand and generic. I have personally noticed a difference for the better with brand. I would suggest a test for those that can afford it. Do one refil brand and see if you feel better/different. I know that's not an option for many, but if you can, wouldn't you like to decide for yourself?
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> I'm sticking to brand and think the 10 times cost or whatever it is worth it for me. Others I personally know who have done the same thing stay with brand after trying it.
>
> Just my take for what it's worth.I wasn't saying you couldn't try it.. but they're still around 5-10 times the price of a generic, which are largely still made in the United States.
Mylan, Canonsburg, PA.
etc.
There are a few drugs, and you have to search the Orange Book, that are listed as possible differences. These are largely drugs for life threatening conditions, where consistency must remain the same. But, one must remember, consistency can also differ at a "brand name" company. I noticed for a while that the colours were slightly different on Cymbalta 20s. Odd.This subject has been debated alot on psycho babble and I dont think this is the last of it. May you have better results if you wish.
Tidings
-- Jay
poster:yxibow
thread:607050
URL: http://www.dr-bob.org/babble/20060205/msgs/607146.html