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Re: Serotonin syndrome » Muad' Dib

Posted by yxibow on February 6, 2006, at 3:29:29

In reply to Serotonin syndrome - Nardil + Stablon (tianeptine), posted by Muad' Dib on February 6, 2006, at 0:13:11

> Is there a risk of such one? How does serotonin syndrome manifest? High BP? High BPM?
>
> Take care.

SS is very serious.

It is defined by:

At least 3 of the following symptoms and signs should be present: altered mental status (probably fairly common), agitation, tremor, shivering, diarrhea, hyperreflexia, myoclonus, ataxia, or hyperthermia.

Hyperthermia = (very) high fever (most common symptom)
myoclonus = jerkiness
ataxia = instability


Mild SS can be treated with propranolol which has some minor serotonin reducing properties.

Major SS is usually treated with cyproheptadine or similar serotonin reducers. In a hospital. Along with Ativan and Klonopin.

And monitoring for up to 48 hours.

It is unpredictable to a degree. Measures are all supportive. Definately not something to be combining with a MAOI without an absolute ok from a doctor.

 

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