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Molecular targets for Schizophrenia-cognition

Posted by jrbecker on January 25, 2006, at 11:00:17

http://pn.psychiatryonline.org/cgi/content/full/41/2/16-a?maxtoshow=&HITS=20&hits=20&RESULTFORMAT=&searchid=1138207954112_3340&FIRSTINDEX=0&tocsectionid=Clinical*&displaysectionid=Clinical+and+Research+News&journalcode=psychnews

Clinical & Research News

Molecular Targets Ranked
Scientists participating in the NIMH-sponsored MATRICS project ranked these molecular targets as the nine most promising targets for development of a drug to treat cognitive impairments in schizophrenia. The nine molecular targets are implicated in seven domains of cognition: working memory, attention/vigilance, verbal learning and memory, visual learning and memory, speed of processing, reasoning and problem-solving, and social cognition.

1. Alpha-7 nicotinic receptor agonists

2. D1 receptor agonists

3. AMPA glutamatergic receptor agonists

4. Alpha-2 adrenergic receptor agonists

5. NMDA glutamatergic receptor agonists

6. Metabotropic glutamate receptor agonists

7. Glycine reuptake inhibitors

8. M1 muscarinic receptor agonists

9. GABA-A receptor selective agonists

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