Posted by yxibow on January 21, 2006, at 1:36:03
In reply to Re: Atypical APs vs sedative antihistamines » yxibow, posted by ed_uk on January 20, 2006, at 13:25:09
> Hi Yxi :)
>
> Promethazine (Phenergan) is not the same as prochlorperazine (Compazine). Prochloperazine (Compazine) is a potent D2 antagonist, similar in many ways to haloperidol (Haldol). Promethazine (Phenergan) is a 'weak' D2 antagonist (as is Seroquel). Both Seroquel and Phenergan are antihistamines.
>
> Regards
>
> EdI realize about the Ki values :) But keep me out of that family nonetheless even if it is because of a horrible experience! They all lead far faster to TD, even Phenergan. Both Phenergan and Compazine are used both for anti-emesis, regardless of their strength. They have also been associated with dystonia and other variants of long term use. I wouldn't recommend them for antihistamine use unless no other A1 and A2 blocker worked for a patient, including doxepin, which is a TCA and yes, even that can cause TD although not as much as other tricyclics I believe. And more novel and compassionate things should be used in place of Compazine yet it is still widely used in medicine when other antihistamines and 5HT3 blockers can be used for anti-emesis. It was one of those cases of going to the hospital and getting sicker than staying home. Almost.
Seroquel in vivo is an antihistamine and explains why I am annoyingly loopy and sedated at night. Doesn't particularly solve any seasonal allargies though. It may dry out some patients, I haven't had that experience. It is fortunately far weaker of a D2 antagonist and occupies those receptors for a briefer portion of the day, than, as noted Haloperidol (or even high dose Risperdal which is just Haldol in molecular disguise.)
poster:yxibow
thread:600777
URL: http://www.dr-bob.org/babble/20060115/msgs/601401.html