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Re: Buspar stories? Weight gain?

Posted by cache-monkey on January 7, 2006, at 13:22:35

In reply to Buspar stories? Weight gain?, posted by Racer on January 1, 2006, at 15:38:26

I tried BuSpar up to 10 mg/day. It decreased my appetite, if anything. But I think it did so because it made my physical anxiety worse. (At the same time I think it helped the psychic component of my anxiety.)

I think the worsening of my physical anxiety had something to do with me being a poor CYP-2D6 metabolizer: the main metabolite of BuSpar, 1-PP, antagonizes the alpha-2 adrenergic receptor leading to more norepinephrine and is cleared by CYP-2D6. If you're a normal for CYP-2D6 metabolism this might not be an issue for you...

Best,
cache-monkey


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poster:cache-monkey thread:594004
URL: http://www.dr-bob.org/babble/20051231/msgs/596236.html