Posted by fachad on January 5, 2006, at 18:29:42
I've heard that because of properties at alpha receptors which become more pronounced at "higher" doses, and eventually eclipse the histamine receptor (sedative) effect - because of that Remeron is actually LESS sedating at HIGHER does.
Does this resonate with people's actual experiences?
The usual anecdote is that at "higher" doses - said to be around 45 mg or 60 mg - Remeron is less sedating. Does that mean that Remeron becomes MORE sedating as the dose increases, UNTIL it goes above 30mg? So is 30 mg more sedating than 15 mg; and 15 mg is more sedating than 7.5 mg? Or are there some people find the alpha thing to kick in at the 30mg dose, making the ideal dose for sleep to be 15 mg?
I know that YMMV, but I'm wondering what mileage people actually get, and how much that jibes with the theoretical data/marketing claims of the manufacturer.
poster:fachad
thread:595567
URL: http://www.dr-bob.org/babble/20051231/msgs/595567.html