Posted by linkadge on December 31, 2005, at 12:03:57
In reply to Re: Revolutionary approach to depression » linkadge, posted by Pfinstegg on December 31, 2005, at 10:42:33
Hey, I would love to take the path you have taken with regards to Tianeptine.
Anyhow my story is similar. No suicidality untill SSRI's. Suicidiality emerged during treatement and slowly deminished after discontinuing.
There was an arugment about this sort of thing before, but there is acually evidence that a large portion of depressives already have a *less* active serotonin reuptake transporter to begin with. People with one or two short varients of the serotonin transporter seem dominate the depressive population.
People with the long varients have been shown to respond better to SSRI's which makes some sence,
since they have a higher reuptake of serotonin, but these individuals seem to be scarce in the depressed population.http://psychiatry.jwatch.org/cgi/content/full/2003/1008/1
This is a bit long but it tries to explain how people with short serotonin allels may have problems with amygdala circutry due to elevated serotonin, and thus explain their high occurance of depression responces to stressfull life events. (It was funny cause a year back there was a little blib about how it seemed counterintuitive to be prescribing SSRI's to this group of people, they got rid of that blib for some reason)
http://www.psycheducation.org/mechanism/4WhyShortsLongs.htm
Another angle is that there have been many false claims about the neuroprotective properties of antdiepressants. The fact is that this line of thinking was spurred by studies with Tianeptine. A lot of doctors just assumed it carried over to other drugs as well. But SSRI's do NOT confer the same neuroprotective properties as tianeptine, and that is an important distinction to make.
p.s. I hope to one day be able to try tianeptine.
Linkadge
poster:linkadge
thread:593368
URL: http://www.dr-bob.org/babble/20051231/msgs/593724.html