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Re: Cymbalta Insomnia- Trazedone? » flipsactown

Posted by yxibow on December 28, 2005, at 22:57:19

In reply to Re: Cymbalta Insomnia- Trazedone? » Dawnie, posted by flipsactown on December 28, 2005, at 20:27:36

> I have been on 60mg Cymbalta for 7 weeks and have been experiencing insomnia for which I take 100mg Trazodone. I sleep very well on Traz getting quality REM sleep. However, I am male and also experience anorgasmia with Traz.

I'm a natural insomniac so I can't say that Cymbalta has contributed significantly to it like Effexor did years ago when I tried it.

>I tried taking Remeron which is also very sedating, but Remeron gives me quite an appetite and I pack on the pounds.

Definately -- I'm just pushing off 40% of it in the gym.

>I hope the sexual side effect of Trazodone will subside in time.

It probably will -- but one thing, and I assume your doctor knows, is that Trazodone and Cymbalta are both metabolized by P450 CYP2D6, which means there is a slight potential for drug-drug interactions. The anorgasmia is probably more due to the Trazodone, but could also be due to the combination.

Decreased libido was reported in 1.3% of the outpatient community in Trazodone tests. Of course then there is "the problem" with Trazodone to watch for in relation to this -- priapism. Occurs more often than not, not to scare you (I experienced it mildly mostly about once every few months but continued to take the drug for a while) -- although if you're younger, you're probably likely not to be in too much danger of such a situation.

 

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URL: http://www.dr-bob.org/babble/20051221/msgs/592932.html