Posted by Jedi on December 26, 2005, at 3:06:40
In reply to Combining Lofepramine with an MAOI?, posted by Tom Twilight on December 24, 2005, at 12:33:03
> Its Christmas Eve and my mood has suddenly slipped drasticly, great! :(
>
> I'm currently on Marplan, which I don't really want to discontinue before taking another AD
>
> The options of what you can combine with an MAOI are a bit limmited, especially in the UK
>
> Presumably Lofepramine can be safely combined with MAOI as its similar to Desipramine
> Which is the only TCA its completely safe to combine with an MAOI
>
> Is that right?Hi Tom,
I've read that lofepramine is extensively metabolized to desipramine in the liver. I haven't studied it enough to know if it can be safely combined with a MAOI. There are effects of the medication other than from the metabolite desipramine. I have combined nortriptyline at 100mg with Nardil at 75mg. Nortriptyline is the major metabolite of amitriptyline. IMHO any of these combinations can be potentially dangerous and should only be administered by an expert in psychopharmacology.
Good Luck,
Jedi
poster:Jedi
thread:591879
URL: http://www.dr-bob.org/babble/20051221/msgs/592195.html