Posted by Larry Hoover on December 23, 2005, at 22:37:06
In reply to Re: Effexor metabolite submitted for FDA approval » Larry Hoover, posted by ed_uk on December 23, 2005, at 18:56:57
> >........just how much this new product will resemble the older Effexor depends directly on how functional your 2D6 is. If you're a poor metabolizer, this will be a novel drug.
>
> .......but venlafaxine *itself* has pretty much the same pharmacological effects as desvenlafaxine. They're both SNRIs of comparable potency.
>
> Regards
>
> EdPerhaps without sufficient evidence, I am presuming some activity (side-effects) from N-desmethylvenlafaxine. The relative proportion of venlafaxine being N-desmethylated would be inversely propotional to 2D6 activity. (I.e. 2D6 being major route or minor route to didesmethylated structure).
I would like to retract my earlier statement re: novelty, as I can find no supporting evidence for my assertion. Binding affinities of venlafaxine and the o-desmethyl structure are virtually identical.
Lar
poster:Larry Hoover
thread:591573
URL: http://www.dr-bob.org/babble/20051221/msgs/591758.html