Posted by ed_uk on December 19, 2005, at 13:28:07
In reply to LOL! You sure give me credit... » ed_uk, posted by Racer on December 19, 2005, at 12:54:09
Hi Racie!
>Any idea what name I might know guaifenesin under?
It's sometimes called GGE.
'General anaesthesia: Infusions
The principal problem with contemporary (anesthetic) techniques (in horses) is the unpredictable duration of action, with the need for frequent (embarrassing) incremental dosing (clients are usually present at field operations). For this reason, and the need to provide more stable conditions, glyceryl guaiacolate ether (GGE), or guaifenesin has become increasingly popular in TIVA (total IV anesthesia) techniques.
GGE is regarded as a spinally-acting muscle relaxant and is used to provide maintenance conditions as part of several total intravenous anaesthetic techniques. It acts as a muscle relaxant and a vehicle for other drugs. Its mechanism of action is poorly understood; it acts on polysynaptic reflex arcs in the spinal cord, reticular formation and sub-cortical areas of the brain in a mephenesin-like manner. Its prominent feature is an ability to depress internuncial neurone transmission in the spinal cord without impairing breathing. In North America, GGE is considered to have CNS depressant effects beyond muscle relaxation; elsewhere, it is not used as a sole anaesthetic but always given with other CNS depressant drugs.'
Hmm, scary to think that American horses might be being operated on while they're awake - but paralysed.
Ed xx
poster:ed_uk
thread:589660
URL: http://www.dr-bob.org/babble/20051211/msgs/590376.html