Posted by Larry Hoover on December 10, 2005, at 10:38:04
In reply to Re: Entering study vs symptoms » Larry Hoover, posted by Cairo on December 9, 2005, at 23:42:32
> Larry,
>
> Did you ever experience "poop out" with either Neurontin or Lyrica?Nope. Couldn't tolerate Neurontin long enough to answer that question, and I've only been on Lyrica for eight weeks.
> What causes this and what recommendations would you have?
I don't know. Both drugs are supposed to work at the spinal cord, blocking delta2 variants of the alpha adrenoceptor, or something like that. I'm not surprised that the body has some way of overcoming having the spinal cord messed with.
I've heard it suggested that you could do a 2 months on, one month off pattern, to avoid any receptor adaptation. I'm going to shrug on that.
> I had it occur with Neurontin and am worried that this would occur with Lyrica also, as suggested by some Lyrica users awhile back on this forum. Thanks!
>
> CairoOne of the biggest differences between these two drugs is that Lyrica has linear pharmacokinetics. If you double the dose, you get double the blood level. Neurontin wasn't like that at all. Doubling the dose might raise the blood concentration by 20% (if you were already at a dose over 1200 mg/day). At least with Lyrica, you have linear dose response.
I don't know what else to say. We're all being guinea pigs with Lyrica.
Lar
P.S. Nortriptyline side effects were really bad, but it affected my pain so subtly, I didn't even notice much. Until I told my doctor I wanted to scrap it, and the pain came back before I got down very far on the dose.
And they have no explanation for why it can help pain. There's so much we don't know. Taking a drug in hopes a side effect might occur is not my idea of how medicine ought to work, but pain makes you try anything. <sigh>
Lar
poster:Larry Hoover
thread:587337
URL: http://www.dr-bob.org/babble/20051203/msgs/587748.html