Posted by gromit on December 5, 2005, at 14:15:04
In reply to README! - Question re Adderall XR w/ multivitamins » gromit, posted by vbAgent on December 3, 2005, at 5:02:19
> Adderall is an amphetamine mixture, and because amphetamines are a basic (NOT acidic) drug, urine pH influences excretion/elimination. Acidifying the urine (e.g., with Orange Juice or Cranberry Juice) hastens the elimination of Adderall, whereas urinary alkinalization (e.g., with sodium bicarbonate or antacids) extends the half-life of Adderall so it becomes reabsorbed in the bloodstream.
That was my understanding too, but to quote from this page http://www.ctds.info/acidic-foods.html
"The effect foods have on urine pH may be quite different than the pH of the foods themselves. For example, orange juice is a highly acidic food due to its high citrus acid content, but after being metabolized it will cause urine to become alkaline".
So I was confused until I just found this http://www.rxlist.com/cgi/generic/amphet_ad.htm
"Acidifying agents - Gastrointestinal acidifying agents (guanethidine, reserpine, glutamic acid HCl, ascorbic acid, fruit juices, etc.) lower absorption of amphetamines".
"Urinary acidifying agents -(ammonium chloride, sodium acid phosphate, etc.) Increase the concentration of the ionized species of the amphetamine".
So it seems a higher ph in your tummy will increase absorption and higher urine ph will slow elimination. I apologize if this was obvious to everyone but me.
Rick
poster:gromit
thread:583067
URL: http://www.dr-bob.org/babble/20051203/msgs/585750.html