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Re: non-SRI drugs not tied to same 6-8 week schedule?

Posted by jamestheyonger on December 5, 2005, at 11:22:45

In reply to non-SRI drugs not tied to same 6-8 week schedule?, posted by iforgotmypassword on December 5, 2005, at 3:40:21

> i thought that the 6-8 week thing is due to serotonin receptor resensitization (presumably 5HT-1A), which can take a while, and that other ADs may take time to kick in, although it is not by the same mechanism.

Reuptake inhibition happens at once, there is no need for a build up, steady state of most meds within a few days; down stream systems seem to adjust over 6-8 weeks with the antidepressant effects kicking in then. 6-8 weeks is also the point neurogenisis starts. Many do see improvement in the first few weeks; reuptake inhibition amps some people up, giving them more energy and many AD's are sedating, which improves sleep or reduces anxiety levels. there is also placebo effect or just the relief you are actively fighting the depression.


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poster:jamestheyonger thread:585094
URL: http://www.dr-bob.org/babble/20051203/msgs/585716.html