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Re: Can I take an SSRI with Depakote?

Posted by med_empowered on December 5, 2005, at 4:12:42

In reply to Re: Can I take an SSRI with Depakote? » ace, posted by Phillipa on December 4, 2005, at 22:36:29

hey! Yeah, SSRI+depakote (or lithium, tegreol/trileptal, etc.) combos are pretty common in bipolar disorder and some depressive disorders. The SSRI *could* cause destabilization, and they come with their own side effects that need to be considered but...it could offer some improvement in mood and anxiety. Sometimes, the mood-stabilizer+ssri combo actually makes both work better; mood-stabilizers sometimes help people with "ssri poop-out" and they can prevent the SSRI from making the mood more erratic, which could hinder progress. Some people who don't respond to SSRIs get pretty good results with Effexor. Since Effexor and Cymbalta are pretty similar, cymbalta may also be worth considering. Adding BuSpar to an SSRI can also help with AD response and anxiety (in some people), although the side effects of the combo are intolerable for some people. Good luck!


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