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Re: Tricyclics and anhedonia

Posted by Squiggles on November 6, 2005, at 10:22:21

In reply to Re: Tricyclics and anhedonia, posted by zeugma on November 6, 2005, at 10:15:20

> > Some people can take a steady dose of a benzo for a very long time. I don't know if the same can be done with opiates.
>
>
> Benzos are not useful in reducing anhedonia as far as I know. Stimulants can be useful, but tolerance is a major problem with them. The same is probably true of any drug that modifies the hedonic response such as opiates. People were so excited about tricyclics when they were discovered because they seemed to modify the hedonic response without inducing tolerance.
>
> -z
> >
> > There have been a few come here who have investigated the topic, but I havn't heard of any long term sucess stories.
> >
> > Linkadge
>
>

I think that benzos work indirectly on
"anhedonia", insofar as they reduce that
part of "unhappiness, lack of motivation,
flat affect, etc." that has to do with
anxiety.

I would not be surprised if stimulants
worked as adjuncts.

I know Dr. Goodwin worked on a paper
on opiates for depression. I would be
VERY surprised if heroin or morphine did
not make you happy. The question is how
to control addiction before it gets
bad for your health. The current drugs on
the pharmaceutical market are not exactly
good for your health (e.g. tricyclics are
cardiotoxic) and some of the benzos are
quickly addicting while others are not.

I suspect a tad of the old fashioned
fear of the evil narcotics about opiates,
that may prevent psychiatritry from
investigating it for depression.

Squiggles


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poster:Squiggles thread:575925
URL: http://www.dr-bob.org/babble/20051106/msgs/575958.html