Posted by SLS on November 4, 2005, at 7:41:12
In reply to Nardil Poopout Club: What else worked for you?, posted by bigcat on November 3, 2005, at 23:57:50
Hi.
My first reaction would be to say that there is probably no benefit from going above 120mg of Nardil a day. I can empathize with the desperation you must be feeling.
I understand your feelings about the use of the word "augmentor". In general (not medical) usage, it means to increase or enlarge something that already exists. So lets just think of augmentation as really being nothing more that coadministration. Sometimes, two drugs will act together synergistically to produce an effect that neither one alone is capable of. For instance, this occurs when one adds lithium to an antidepressant that has shown no signs of working. If I were in your position, I would try to augment the Nardil before having to discontinue it in order to move on to a serotonin reuptake inhibitor (SRI) drug. Something that I have had limited success with is adding desipramine to Nardil. My only caveat about adding this tricyclic (TCA) drug is that it be titrated very gradually to avoid side effects. There really is not much of a safety issue with desipramine. However, desipramine is the only TCA that I would recommend as it is the only one that does not act as an SRI to some degree. I guess one could make the argument that trimipramine would also fit into this category, but since I have no experience with it, I cannot recommend it.
Among the things you can add to Nardil safely, are:lithium
Lamictal
desipramine (Norpramin)
Wellbutrin
amphetamine (Dexedrine, Adderall)
methylphenidate (Ritalin, Concerta)
Trileptal
RemeronTell me, are there any hints of bipolar disorder in your case or in your family history?
- Scott
-------------------------------------------------> I'm on 105mgs Nardil, 225mgs Lamictal, and 60 mgs Aderall- had a great initial response (as always happens when I go back on the Nardil). Right now nothing whatsoever (not 30% or 40%- it's doing nothing). While I'm still entertaining augmenting options, "augmenting" implies enhancing an existing, though not complete, response. While my remission last week was very real and powerful, the Nardil is essentially a sugar pill at this point and I've quickly returned to my familiar, severe depression.
>
> I was wondering if anyone with a similar Nardil experience found success with other treatmnet options...TCA's, SSRI's, SNRI's, etc. (This could indicate what might be a good option for my next trial). Marplan worked for a couple months before fading out, the Parnate did nothing but give me insomnia (I was only at 90 mgs). I have considered, as wild as it sounds, taking the Nardil to unheard of doses (+135mgs, closely monitoring blood pressure and other side effects- nothing to lose at this point). I'd appreciate any thoughts or experiences.
>
> Your Friend In Need,
> -matt-
>
>
poster:SLS
thread:575240
URL: http://www.dr-bob.org/babble/20051031/msgs/575284.html