Posted by ed_uk on October 29, 2005, at 14:51:04
In reply to Re: alpha-2 agonists for cognitive clarity, posted by sdb on October 29, 2005, at 3:05:57
Hi S,
Bendroflumethiazide 2.5mg is the most popular anti-hypertensive in England. It's very similar to hydrochlorothiazide.
Here is some info RE moxonidine.........
In different animal models, moxonidine (Physiotens) has been shown to be a potent antihypertensive agent. Available experimental data convincingly suggest that the site of the antihypertensive action of Physiotens is the central nervous system (CNS). Within the brainstem, Physiotens has been shown to selectively interact with I1-imidazoline receptors. These imidazoline-sensitive receptors are concentrated in the rostral ventrolateral medulla, an area critical to the central control of the peripheral sympathetic nervous system. The net effect of this interaction with the I1-imidazoline receptor appears to result in a reduced activity of sympathetic nerves (demonstrated for cardiac, splanchnic and renal sympathetic nerves).
Physiotens differs from other available centrally acting antihypertensives by exhibiting only low affinity to central alpha2-adrenoceptors as compared to I1-imidazoline receptors; alpha2-adrenoceptors are considered the molecular target via which sedation and dry mouth, the most common undesired side effects of other centrally acting antihypertensives (eg. clonidine), are mediated.
In humans, Physiotens leads to a reduction of systemic vascular resistance and consequently in arterial blood pressure.
Kind regards
Ed
poster:ed_uk
thread:572716
URL: http://www.dr-bob.org/babble/20051024/msgs/573088.html