Posted by lunesta on October 28, 2005, at 21:34:25
In reply to Re: Gabapentin/Neurontin - depression and anxiety » lunesta, posted by SLS on October 28, 2005, at 18:54:29
Lyrica is just a glorified neurontin and much more dangerous, which is why its a controlled substance, just like neurontin should be.
Neurontin effects substance P, which is involved in emesis (vomiting), anxiety, sleep, mood, pain and many more things. Its thought mode of action is binding to the alpha2delta aux high voltage calcium channels. It causes a decrease in spinal level glutamate, indirectly raises gaba, hits the gaba-b autoreceptors or something in the gaba-b unit, which they dont know, but similar to where GHB hits, effects opioiergic system indirectly modulating endomorphin-1 and 2 probably through substance P/NK1, alters+interacts w/ vasoactive intestinal peptide, decreases all neurotransmitters (main ones) serotonin, norepinphrine, and dopamine, however it effects dopamine in some special way which is unknown as of yet but may be mediated by substance P. Withdrawl can cause edema of the brain, pyscosis, hyperemesis, opiate/alcohol/benzo withdrawl combined type effects and permanant panic attacks due to screwing with substance P in the amygdaloid nucleus as well as eating behavior and sexual function and so many other things , use it at your own risk. I have personal experience with neurontin long term high dose, this is why i know a lot. The withdrawl ruined much of my life I am messed up quite a bit. Many reports on the net of this, and you of course know of the class action lawsuit against pfizer for lying about neurontin.
Do not use this off label unless you plan to be on it forever. It is OKAY for short amounts of time, similar to a benzo.
good luck.
poster:lunesta
thread:572445
URL: http://www.dr-bob.org/babble/20051024/msgs/572911.html