Posted by lunesta on October 26, 2005, at 21:23:06
In reply to Any remedy for DA Receptors Tolerance?, posted by neo on October 26, 2005, at 20:15:24
yousing the reverse antagonist of whatever receptor you are hitting will upregulate it, so taking an agonist will downregulate it.
example, a neuroleptic will upregulate the dopamine receptor, this isnt good for schizophrenics because they may never be able to get off.
to downregulate it, you would need to target the exact receptor with the opposite medicine which would antagonie it for a period of time and 'normalize it'
the perfect example is naltrexone, the opiate receptor antagonist. If you have tolerance to opiates, go off of them, then use naltrexone for the same period of time you used opiates or so, the receptors will upregulate and work again. so when you take codeine again after awhile, it will hit you hard, like you never took it before.
Amisulpride is interesting. At low doses it is a dopamine agonist, very similar to Survector actually. At higher doses, it is an antagonist. So you can play around with it a bit.
poster:lunesta
thread:572106
URL: http://www.dr-bob.org/babble/20051024/msgs/572233.html