Posted by SLS on October 13, 2005, at 12:02:08
In reply to Re: nardil-more NE and DE at higher doses » tecknohed, posted by 4wd on October 10, 2005, at 23:47:21
> If Nardil is sedating why does it cause insomnia?
Hi Marsha.
Have you ever felt really tired, fatigued, and subdued without being sleepy? Have you ever been sleepy and still not able to fall asleep? Nardil seems to possess both stimulant and sedative properties. I don't want guess at the mechanisms behind each of these. It is tempting to want to always explain things by looking only at the "levels" of the three main monoamine neurotransmitters (NE, DA, 5-HT). It is quite possible that the insomnia is not caused by MAO inhibition, but rather by some other unrelated pharmacological property. Alternatively, MAO inhibition might be responsible for divergent activities in different brain circuits that are normally kept in balance by feedback mechanisms between the two that can no longer be maintained because of the indescriminant increase in neurotransmitter levels.
Parnate is a different beast in that it can cause profound sleepiness during the middle of the day and insomnia at night. Some of this might be due to the amphetamine-like effects of the drug and its metabolites.
- Scott
poster:SLS
thread:565365
URL: http://www.dr-bob.org/babble/20051010/msgs/566471.html