Posted by SLS on September 26, 2005, at 8:25:30
In reply to Re: Has anyone tried Rozerem yet? (new sleep drug), posted by jack2000 on September 25, 2005, at 16:31:35
Hi.
Have you been diagnosed with hypernychthemeral syndrome or DSPS? If not, what, if any, diagnosis have your doctors given you?
Have you ever tried high dosages of vitamin B12 or magnesium? I have seen these mentioned when dealing with chronobiological disorders. Also, reduced exposure to light late in the day might help as some people with DSPS are hypersensitive to light-induced melatonin suppression.
I don't think it is a good idea to avoid Rozerem or agomelatine when it becomes available. Although both drugs are melatonin receptor agonists, I don't think there is enough data on how these drugs work to exclude them from consideration. Perhaps these drugs need to immitate the natural release of melatonin to be effective in chronobiological disorders. That would be at 2:00am for someone trying to keep a 11:00pm - 7:00am sleep schedule. Perhaps very dosage is all that is necessary.
Maybe, maybe, maybe... I know. I'm just thinking out loud. So little is understood about the etiologies and treatments of chronobiological disorders. Perhaps a melatonin antagonist would be of some use if Rozerem exacerbates the situation.
SSRIs can sometimes make things worse.
- Scott
poster:SLS
thread:532130
URL: http://www.dr-bob.org/babble/20050921/msgs/559736.html