Posted by iforgotmypassword on September 21, 2005, at 14:07:57
(PLEASE SHARE YOUR OPINION ON WHAT YOU THINK WORKS. IF MY EXPERIENCE BELOW IS TOO LONG TO READ, ANYTHING YOU COULD SHARE ON THE GENERAL TOPIC WOULD BE AWESOME. THANX.)
i remember desipramine helping me cry and overcome reversed vegetative symptoms (hypersomnia and ridiculous apppetite). i felt like some of my feeling was coming back, like i could be a real person again, but it always feel through. i was still never able to say or do anything meaningful. i would trade this lack of feeling for despair and i don't know if i would regret it, at least i would be a feeling individual again. i can't say that desipramine really helped for motivation/drive, but i certainly noticed the increased difficulty i would get if i negected to take it. still it was the only drug that really came close to helping.
i have my doubts about maois... they seem to be possibly dopaminergic, but don't increase the expression of dopamine receptors like other ADs do (venlafaxine, fluoxetine, desipramine)... and they hit serotonin receptors rather crudely (seems to be without decreasing expression of 5HT-2 like high dose venlafaxine is supposed to do) and i worry about anything intensely noradrenergic as im worried about my temper getting worse... ugh... i also tried parnate (40mg) and wasn't even sure if i felt anything. :(
i have tried every SSRI available. some doctor thought venlafaxine was helping but i don't know if he really knew what he was talking about. (i also started to forget to take it on a pretty regular basis) maybe if i start it with mirtazapine (Remeron) concomitantly with effexor i might get a better response. or would Zyprexa be a better idea? there seems to be so much out there suggesting that Effexor is superior, aside from it seeming to be the most relied on antidepressant these days, and all the success stories, it even seems to have effects on opiod, D3, and 5-HT2 receptors on the long term... they seems pretty important to presumed atypical depressives like me.
the main drugs my doctor keeps bringing up are nardil and nortriptyline, but i worry about both of those drugs. nardil i hear of all sorts of side effects, and seems to be predominantly serotonergic (whats so special about it?), and nortriptyline's reports of the tricyclic dumb-drug effects really worry me... and any sedation... my doctor didnt think it made much sense. but i worry.
tomorrow is my last day in the inpatient evaluation programme and we need to know what we are doing for my medication RIGHT AWAY. i am being referred back to my old pdoc with recommendations, but he is very unhelpful and doesn't seem very eager to help me. he also isn't ever very open to creative pharmacology. so i need to know what direction to go in asap. :(
poster:iforgotmypassword
thread:557669
URL: http://www.dr-bob.org/babble/20050921/msgs/557669.html