Posted by Chairman_MAO on September 21, 2005, at 13:48:34
In reply to Re: try buprenorphine + memantine + tranylcypromine » Chairman_MAO, posted by SLS on September 18, 2005, at 9:02:20
The first thing you should do IMHO is chuck the abilify and use a modern, FULL dopamine agonist instead (ropinirole, pramipexole, cabergoline). As for its 5ht2 antagonism, won't the nortryptiline do enough of that? It's an intuition of mine that if someone is on more than three psych drugs administered for psychoactive purposes, something is not working.
Cabergoline is affordable from www.mastersmarketing.com, and you only have to take it once per day. From case reports, it's my impression that the antidepressant augmentation dose is around 2.5mg/day. You can probably nix the lamictal when you add the memantine, and quite possibly nix the notryptiline when you add the bupe. I would also recommend working the tranylcypromine dose up to at least 120-150mg/day, maybe even 200mg/day; doses lower than 90-120 do not have the effects on 5ht2 density that phenelzine and higher TCP doses do, IIRC. At high enough TCP doses, its metabolites will probably give you enough NE uptake inhibition such that you will not need a TCA if you are taking bupe and memantine. All conjecture, of course.
poster:Chairman_MAO
thread:554111
URL: http://www.dr-bob.org/babble/20050921/msgs/557665.html