Posted by Chairman_MAO on September 13, 2005, at 13:03:05
In reply to Re: Cialis can cause anorgasmia/Nardil update (goo » SLS, posted by iforgotmypassword on September 13, 2005, at 10:26:55
> it seems that not only do you need a doctor that prescribes them, but also one that is willing to push the dose into an actual effective range (a doctor i had was not willing to go over 40mg with the parnate), because they recognize their own concept of what an "effective range" is.
Even when my pdoc at the clinic in New Brunswick was a resident, she was still comfortable with writing a script for up to 80mg/day tranylcypromine. Back then I had no medicaid, so I ended up buying the Parnate from a chemical supply house and encapsulating it myself (I knew someone with a USP-spec capsule filler). When I had my own stock and she didn't have to write the script, I was totally open with her about taking 120-200mg/day and there was no chastizing of me.
Now my doctor is the guy who supervised her. While I do not know if he'd be comfortable using ultra-high doses, I do know that they have no problems going up to 80mg/day Parnate or 90mg/day Nardil. If for some reason you fail to respond at all, there is some likelihood they'd push the dose higher. I am not certain of that, however.
>
> btw, chairman mao, it is great to hear that you are doing so well.
Thanks. After being mentally ill in some capacity for most of my life, it's a breath of fresh air for sure.> it makes me wonder what it is about serotonergic meds that cause sexual dysfunction,
maybe 5HT2 overstimulation? i wonder if there is
The 5ht2 stimulation inhibits dopamine release.
With MAO inhibitors, if there is too much MAO inhibition, there can also be a concomitant fall of DA synthesis. Too much SE can also raise prolactin levels due to inadequate stimulation of D2 receptors in the hypothalamus. This is why the drug cabergoline seems to work so well for sexual dysfunction from serotonergic medications--in addition to eliminating the male refractory period (only with intermittent dosing).>also a noradrenergic component as well, as when i was on desipramine i was very sexually unresponsive to touch.
Stimulation of alpha adrenoreceptors in the male reproductive tract impairs blood flow and consequentially sensitivity as well.
The whole story is WAY more complex than this.
poster:Chairman_MAO
thread:554608
URL: http://www.dr-bob.org/babble/20050909/msgs/554665.html