Posted by Chairman_MAO on September 13, 2005, at 9:02:08
In reply to Re: To Willyee, posted by denise1966 on September 12, 2005, at 8:17:22
MAOI + buprenorphine is the most robust antidepressant combination I have ever taken. I have recently discontinued the buprenorphine because I believe it was worsening the sexual side effects from Nardil. I hope this isn't a transient thing, but as of now I only have a slightly delayed orgasm @ 90mg/day; no impotence, no anorgasmia. I will be quite frustrated if this is only due to withdrawal from the bupe and doesn't last.
If MAOIs failed you outright, buprenorphine is one of the next logical options. If you can fudge or have a substance abuse problem, you can get Suboxone (buprenorphine/noloxone sublingual tabs). If not, a "cavalier" doctor can prescribe bupe amps to be taken subligually four times per day.
Babblemail me if you need literature to show your doctor on the use of buprenorphine for treatment-resistant depression. Unlike typical opioids, you cannot overdose on it (except via injection along with benzodiazepines), and there is a "ceiling" concentration (mu partial agonist effect) past which it will not stimulate the receptors more. Moreover, I have had minimal-to-no withdrawal reactions upon discontinuing it. I keep it around in case I ever feel really horrible, because it works for "breakthrough depression" and anxiety if taken as-needed.
poster:Chairman_MAO
thread:553620
URL: http://www.dr-bob.org/babble/20050909/msgs/554594.html