Posted by yxibow on August 31, 2005, at 15:24:00
In reply to Re: Is Clonazepam a high potency benzodiazepine?, posted by Glydin on August 31, 2005, at 9:13:50
> The half life of Klonopin is anywhere from 18-50 hours by most resources. It has been my observation most routine users dose several times a day, therefore I think there lies a potential for the actual drug level to be more than one would expect based on dose due to the overlap. I would think this would be very individual with many factors of metabolism and clearence specific to one person to another.
This is true.. however "in vivo" (animal) and "in vitro" (man) studies of half life differs wildly. The typical half-life of clonazepam more averages 12-16 hours, hence twice daily dosing.
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> I believe the potency and strength of benzo's are dose and individual dependent. This seems to be borne out with the relaying of experiences in comparing - "this one snowed me, this one didn't". For alot of folks it appears to be a trial and error situation.Definately... and some people are "fast metabolizers" of medication (I think that includes myself), and eliminination occurs earlier.
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> I get the feeling you are not satisfied with your response and I remember your doc is reluctant to RX another benzo for whatever reason. If this were the case for me, I would go in search of another doc.I would be careful when "shopping" for doctors for C-IV medication -- one, there may be a reason why one's current doctor is hesitant (multiple drug combinations), and two, one doesn't want to look like one is seeking controlled substances. Do a little research and present a case for another benzodiazepine.
Valium is a valid alternative to Klonopin, never mind the 60s comments about "mother's little helper" -- it has a long half life and less risk for inter-dosal dependency.
More obscure ones include Quazepam exists although generally used more for sleep but all benzodiazepines are used off label these days; and the obscure ones prazepam (Centrax), Serax (oxazepam), Tranxene (clorazepate) (I had difficulties with inter-dosal use with tranxene so one might be cautious with that one).
poster:yxibow
thread:548998
URL: http://www.dr-bob.org/babble/20050827/msgs/549253.html