Posted by linkadge on August 29, 2005, at 12:14:24
In reply to Why do antidepressants make me feel worse?, posted by denise190466 on August 29, 2005, at 10:54:48
Here's my take on it.
We don't know why antidepressants work. The serotonin theory is *not* concrete.
We know now that the serotonin theory is *not* concrete because we have a drug called Tianeptine (which is an effective antidepressant) which is a serotonin reuptake accelerator (it does the opposite to what SSRIs do, it speeds the reputake of serotonin, instead of inhibiting the reputake of serotonin).
Nobody knows why AD's will work for some people and not for others.
It may very well be hormonal. As a teenager, SSRI's seemed to work, maybe because I needed the extra serotonin to calm down the testosterone induced irritability. As I get older maybe I need more of a dopaminergic who knows.
I would personally try a different antidepressant.
If it makes you suicidal, then that is unnacceptable. Don't let the notion that MAOIS are *supposed* to be more effective controll you, the most effective AD is the one that works for you.
I know plenty of people who have gone psychotic on MAOI's. They are powerfull pills that alter a large number of neurotransmitters.
serotonin, norepinephrine, dopamine, gaba, PEA etc. Maybe the nardil is not hitting the target, and maybe hitting the wrong targets.
Linkadge
poster:linkadge
thread:548105
URL: http://www.dr-bob.org/babble/20050827/msgs/548138.html