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Re: TCAs, irritability, and BPD.

Posted by tygereyes on August 15, 2005, at 21:25:58

In reply to Re: TCAs, irritability, and BPD., posted by ed_uk on August 15, 2005, at 19:05:50

> >Depression is a big one ... plus, general mood swings, agitation/irritability/hostility ... body dysmorphia, hysterical fear of abandonment, and self-destructive behavior...
>
> What have you tried so far?
>
> ~Ed

I currently take Trileptal (600 mg - anything higher causes cognitive deficits), Seroquel (25 mg and 25 mg PRN) and Desipramine (100 mg).

In the past I have taken:
Zoloft - amazing, amazing response, improved mood AND body dysmorphia, no irritability/hostility, but SSRIs cause enuresis (bed-wetting) and worsen my other Interstitial Cystitis symptoms
Prozac - no response, caused enuresis/worsened IC
Celexa - no response, caused enuresis/worsened IC
Effexor - minimal mood response but caused enuresis/worsened IC
Cymbalta - no response, caused enuresis/worsened IC
Lamictal - not on it long enough to exhibit response, caused enuresis/worsened IC
Zonegran - no response, cognitive deficits present, caused weight loss
Wellbutrin - brief trial so no chance for response, taken off of it when started relapsing into anorexia
Nortriptyline - depression improved but caused irritability/hostility and weight gain
Clomipramine - brief trial so no chance for response, discontinued when appetite sharply increased
Zyprexa - VERY brief trial (one day!), discontinued because of appetite increase and bingeing behavior
Risperdal - amazing response in terms of body dysmorphia and body image distortion as related to anorexia but caused enuresis/worsened IC so had to stop taking it

Trileptal and Seroquel, without Desipramine, have led to enuresis before, so I can't take those two without a tricyclic. Some drugs (Zoloft, Risperdal, Lamictal) have such a profound effect on my bladder that even a tricyclic does not fix the problem. I am hoping that if I try Parnate, this will not occur. If it does, I could always go back to the combination I'm on now - but the irritability/hostility/agitation is just so overwhelming.


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poster:tygereyes thread:540851
URL: http://www.dr-bob.org/babble/20050811/msgs/542208.html