Posted by Shawn. T. on August 5, 2005, at 1:37:24
In reply to Question about med-induced carbohydrate cravings, posted by Sarah T. on August 4, 2005, at 21:49:30
One mechanism involved in some medication- induced carbohydrate cravings is the blockade of serotonin 5-HT2C receptors. When certain 5-HT2C receptors are activated, they cause the release of a peptide called alpha-MSH from neurons in the hypothalamus. alpha-MSH activates MC3 and MC4 melanocortin receptors to reduce appetite. So when 5-HT2C receptors are blocked by a 5-HT2C antagonist like Remeron, alpha-MSH release is probably reduced. The big picture is more complicated than that, but it's a good example of what we do know about the phenomenon. Drugs that affect the melanocortin receptors, especially MC4, are currently in development. In the distant future, these drugs will likely be used to counteract the effects of certain medications on appetite.
Shawn
poster:Shawn. T.
thread:537651
URL: http://www.dr-bob.org/babble/20050803/msgs/537727.html