Posted by ed_uk on August 3, 2005, at 16:36:30
In reply to Flupenthixol (Depixol) » xbunny, posted by ed_uk on August 3, 2005, at 15:16:08
Psychiatr Prax. 2003 May;30 Suppl 2:S94-6.
[Comparative effectiveness of flupenthixol and risperidone on negative symptoms of schizophrenia]
[Article in German]
Philipp M, Lesch OM, Schmauss M, Dose M, Glaser T.
Bezirkskrankenhaus Landshut, Prof.-Buchner-Strasse 22, 84034 Landshut.
The efficacy of flupentixol and risperidone were compared in a randomized double-blind study in 153 chronic schizophrenic patients. Flupentixol showed to be not inferior to risperidone concerning schizophrenic negative symptoms at week 8, 16 and 24. Positive symptoms and general psychopathology improved comparably, too. There was a trend in favor of flupentixol concerning the improvement of depressive symptoms and a trend in favor of risperidone concerning the improvement of preexisting parkinsonian symptoms. The study data justify to regard flupentixol as a "partial atypical" antipsychotic.
Fortschr Neurol Psychiatr. 2000 Apr;68 Suppl 1:S38-41.
[Flupenthixol--a partial atypical neuroleptic?]
[Article in German]
Kuhn KU, Meyer K, Maier W.
Klinik und Poliklinik fur Psychiatrie und Psychotherapie Rheinische Friedrich-Wilhelms-Universitat Bonn. k.u.kuehn@uni-bonn.de
There is no really clear-cut definition for "atypical" neuroleptics. The most convincing definition is draft by characterization of the receptor-binding profile. Most important are: the combined antagonism of D2 and 5-HT2 receptors, the preferential binding to D4 and D3 receptors and a balanced relation of D2 to D1 antagonism. Flupentixol fits into this description as well as some modern neuroleptics widely considered as "atypical" neuroleptics. Clinical criteria--like the absence of EPMS and the improvement of negative symptoms--offer no clear-cut distinction between "typical" and "atypical" neuroleptics, too, because some modern "atypical" neuroleptics lead--dose-dependent--to EPMS, and there is no proven efficacy for some atypical neuroleptics in the treatment of negative symptoms. So, neuroleptics are labelled "atypical" if there is a favourable relation between antipsychotic activity and the degree of EPMS, and if there is at least some efficacy in the treatment of negative symptoms. In this regard, Flupentixol has to be labelled at least a "partial atypical neuroleptic".
~ed
poster:ed_uk
thread:535356
URL: http://www.dr-bob.org/babble/20050803/msgs/537173.html