Re: indiplon, zolpidem -- what's the difference? » ed_uk

Posted by Shawn. T. on July 30, 2005, at 17:05:50

In reply to Re: Indiplon, Lunesta-- what's the difference? » Shawn. T., posted by ed_uk on July 30, 2005, at 16:36:51

Indiplon has a ~10 fold greater affinity than zolpidem for GABA-A receptors that contain the alpha1 subunit (http:/www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15256540). Also, indiplon has a shorter half-life (~ 30 minutes) than zolpidem (~ 2.5 to 2.6 hours). As a result, I imagine that the modified release (MR) version of indiplon will be more popular than the immediate release (IR) version.
Shawn

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Indiplon, Lunesta-- what's the difference? Jakeman 7/30/05
Re: Indiplon, Lunesta-- what's the difference? Shawn. T. 7/30/05
Re: Indiplon, Lunesta-- what's the difference? » Shawn. T. ed_uk 7/30/05
Re: indiplon, zolpidem -- what's the difference? » ed_uk Shawn. T. 7/30/05
Re: indiplon, zolpidem -- what's the difference? » Shawn. T. ed_uk 7/30/05

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