Posted by ed_uk on July 19, 2005, at 17:38:53
In reply to D-2 blockade, Akathisia, Amantadine, Smoking » ed_uk, posted by cache-monkey on July 19, 2005, at 1:04:55
Hi,
>Out of curiosity, how, exactly, does it feel for you when your D-2 receptors get blocked?
Absolutely dreadful. I had to go to the ER after I took Thorazine. I needed 60mg Valium to calm my agitation and akathisia. I was writhing. I wished I was dead. I felt overwhelming panic and extreme motor restlessness. I couldn't be still for more than a second. I felt awful from head to toe, like my muscles were going to explode. I couldn't think normally either, I felt quite confused.
>Amantadine actually made me feel worse.
Have you tried an anticholinergic? I'm not recommending it I'm just curious. I think it would be better to d/c the AP if it isn't helpful at a lower dose.
>One thing I'm worried about, though: does agonising the a receptor lead to down-regulation?
It can do. I'm not sure whether this applies to the D2 receptor though.
Kind regards
~Ed
poster:ed_uk
thread:528069
URL: http://www.dr-bob.org/babble/20050718/msgs/530208.html