Posted by ed_uk on July 18, 2005, at 13:29:15
In reply to Maximum dosage for Stablon (tianeptine), posted by sukarno on July 17, 2005, at 23:33:39
Hi!
Some people take A LOT!
'We report on a tianeptine dependence lasting for eighteen months in a 42 year old patient............Tianeptine was prescribed for a major depressive disorder. The patient alleged a "flash sensation" like with heroin since the very first doses with a physical and psychological well-being sensation, better psychomotor performances and transient mood elation. His addiction to tianeptine was immediate and heavy. The positive reinforcement faded away after one month and a total dependance took over, with physical and psychological withdrawal symptoms when doses were not renewed. After two months of treatment, the daily consumption of tianeptine was of 90 tablets. The patient was hospitalised to treat both the addiction to tianeptine and the ongoing major depressive disorder. He was taking 240 tablets daily.'
'The authors report a case of tianeptine abuse in a 30 year-old woman. After a medical prescription of the recommended dosage of 12.5 mg 3 times daily of oral tianeptine for a depressive illness, the patient spontaneously increased the dosage which after two months reached 150 tablets per day. No severe toxic effects were observed. As adverse effects, the patient, in the beginning of this high treatment period suffered from nausea, vomiting, abdominal pain, anorexia with weight loss, constipation. These side effects progressively disappeared. The biological tolerance was excellent, and hepatic parameters were not affected. The patient experienced and seek a psychostimulant effect. After seven months of such a therapy, she was hospitalized to undergo a withdrawal. The discontinuation of the tianeptine treatment occurs in four days. A withdrawal syndrome marked by myalgia, and cold feeling was transient, and alleviated by sedative phenothiazine (cyamemazine) and myorelaxant benzodiazepine (tetrazepam).'
>I kept trying to ask him if there is a maximum dosage.......
Manufacturers will only ever recommend the approved dose. They are protecting themselves from litigation in case anything goes wrong.
>I do recall reading in clinical trials that Stablon was used up to 75mg/day in divided doses, so that would be 6 tablets a day.
Get your liver function tests measured! Liver toxicity seems to be a concern.
Kind regards
~Ed
>
poster:ed_uk
thread:474445
URL: http://www.dr-bob.org/babble/20050718/msgs/529559.html