Posted by SLS on July 14, 2005, at 7:05:22
In reply to Re: To SLS, posted by Denise1966 on July 14, 2005, at 5:37:59
Hi Denise.
Scenario 1:
The possibility exists that what you experienced upon the discontinuation of Nardil was a neurochemical rebound of sorts that was potentiated by the addition of Seroxat within the first few weeks. I think it depends how long you continued to respond to Seroxat as to the possibility that this is what happened. For me, the rebound improvement from discontinuing Nardil can last for up to four weeks. It is mild, but there. To add another antidepressant during this time can work better if its effects act synergistically with the rebound. It might be that the Seroxat unmasked this neurochemical rebound that remained occult, resulting in the improvement you experienced. If this is true, the combination of moclobemide with an SSRI will likely fail.Scenario 2:
The other mechansism that might contribute to a synergism is that there was a residual amount of MAO inhibition when you began taking the Seroxat. This is what you and your doctor are betting on. One thing that argues for this possibiility is that MAO activity does not return quickly after discontinuing Nardil. The system recovers more slowly after Nardil discontinuation than Parnate discontinuation. Perhaps you and your doctor are right about how the Seroxat worked the last time you tried.How long did the Seroxat work for?
If it was for less than a month, I would guess that the first scenario is true. If it lasted for several months, I would look more towards the second scenario as being accurate, in which case the moclobemide + SSRI combination remains an exciting proposition.
- Scott
poster:SLS
thread:527060
URL: http://www.dr-bob.org/babble/20050713/msgs/527442.html