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Re: difference between auto- and heteroreceptors

Posted by Shawn. T. on July 10, 2005, at 6:14:15

In reply to difference between heteroreceotirs and autorecepto, posted by linkadge on July 9, 2005, at 22:07:04

A 5-HT1B autoreceptor decreases the synthesis & release of serotonin. A 5-HT1B heteroreceptor decreases the synthesis & release of some other neurotransmitter or neuromodulator. 5-HT1A receptors are autoreceptors on cell bodies or dendrites. 5-HT1B and 5-HT1D are autoreceptors at axon terminals. Full agonists can desensitize these receptors after chronic use, resulting in a decreased effect upon synthesis/release. Partial agonists cause less desensitization and therefore may decrease synthesis/release to a greater degree than full agonists when chronically administered.

Shawn


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poster:Shawn. T. thread:525588
URL: http://www.dr-bob.org/babble/20050708/msgs/525663.html