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Re: How is it... » sabre

Posted by SLS on June 4, 2005, at 8:01:38

In reply to Re: How is it..., posted by sabre on June 4, 2005, at 1:53:04

> Hi Scott

Hi Sabre.

> When you take all these medications, do you get side effects or are these minimal too?

That's the scary part. When I first began taking these drugs 20 years ago, their side effects were significant and persistent. With what I'm taking now, I might as well be on sugar pills for all the side effects I get. My central nervous system has accomodated to these drugs too well. If it can now reject the negative side effects, I can't help but to think that it can now reject the positive therapeutic effects with the same efficiency. Perhaps most scary is that the Parnate no longer suppresses REM sleep as I always dream. When Parnate + desipramine did work for me in 1987, I didn't have a single dream in the entire 9 months I took it.

> Do any of them counter the effect of others?

That is always a good thing to look at. Right now, I don't think so.

> Have you tried combining them with exercise?

Yes. Exercise does very little for me, regardless of intensity or duration. I plan to pick up with regular exercise again soon. It can't hurt. Maybe it will help keep my body running until my brain catches up - even if that is at age 90.

> I have read about how it can heighten the levels of drugs in blood plasma eg beta blockers.

I didn't know that. Thanks.

> I suppose the other possibility might be that changing serotonin, NA or GABA isn't the answer for you.

It would appear not. :-(

> You'd think that researchers would have taken all the extreme reactors and extreme non reactors and looked at what makes them different.

Good idea. This is only now being studied.

> Are there any new drugs in the pipeline that you are hanging out for, Scott?

There are a few. One that interests me is a drug called agomelatine. It is a potent agonist at melatonin receptors and an antagonist at serotonin 5-HT2c receptors. The pipeline is relatively empty on the output side. There are a bunch of things being looked at near the beginning of the pipeline. However, these things wouldn't see the pharmacy shelves for another 10 years. You never know when we will be surprised by something that sneaks through without much notice, though.

> I hope you find an answer soon.

Thanks, Sabre. If I do, you can bet that you guys will be the second to know (I'll be the first).


- Scott

 

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