Posted by Nickengland on June 1, 2005, at 13:56:11
There was me thinking that my kidney pain was hyponatremia and something to do with low sodium in the blood.....
Wrong!...It was actually *Nephritis* which is basically an inflammation of the kidneys. Its so strange as the best way to describe the pain was like something was swollen around my kidneys.
In the medical news as of April 2005 for Trileptal is this warning..I hope people on this board do not experience any of this like I have, as all in all this has been the best medication to contol my mood so far. Unfortnately though I am now having to stop Trileptal completely because of the reaction i've had from it :-(
Epilepsy treatment may cause dermatologic problems, drugmaker says
April 20, 2005ST. LOUIS (MD Consult) - On April 19, 2005, Novartis Pharmaceuticals and the U.S. Food and Drug Administration (FDA) notified health care professionals about revisions to the Warnings and Precautions sections of the prescribing information for Trileptal (oxcarbazepine) tablets and oral suspension. The drug is indicated for use as monotherapy or adjunctive therapy in the treatment of partial seizures in adults and children aged 4 to 16 years with epilepsy. The updated Warnings section describes serious dermatologic reactions that have been reported in both children and adults in association with Trileptal use. The Precautions section has been updated to include language regarding multiorgan hypersensitivity reactions that have been reported in association with use of the medication.
The following information regarding multiorgan hypersensitivity reactions has been inserted to the Precautions section of the Trileptal prescribing information:
Precautions
Multiorgan hypersensitivityMultiorgan hypersensitivity reactions have occurred in close temporal association (median time to detection, 13 days; range, 4-60) to the initiation of Trileptal therapy in adult and pediatric patients. Although there have been a limited number of reports, many of these cases resulted in hospitalization and some were considered life-threatening. Signs and symptoms of this disorder were diverse; however, patients typically, although not exclusively, presented with fever and rash associated with other organ system involvement. Other associated manifestations included lymphadenopathy, hepatitis, liver function test abnormalities, hematologic abnormalities (eg, eosinophilia, thrombocytopenia, neutropenia), pruritus, nephritis, oliguria, hepato-renal syndrome, arthralgia, and asthenia. Because the disorder is variable in its expression, other organ system symptoms and signs, not noted here, may occur. If this reaction is suspected, Trileptal should be discontinued and an alternative treatment started. Although there are no case reports to indicate cross sensitivity with other drugs that produce this syndrome, the experience amongst drugs associated with multiorgan hypersensitivity would indicate this to be a possibility (see Warnings, Patients with a Past History of Hypersitivity Reaction to Carbamazepine subsection).
Additional language regarding serious dermatologic reaction and multiorgan hypersensitivity have been inserted under the Information for Patients heading of the Precautions section of the prescribing information and are related to these important changes to the Warnings and Precautions sections of the prescribing information.
Kind regards
Nick
poster:Nickengland
thread:506310
URL: http://www.dr-bob.org/babble/20050601/msgs/506310.html