Posted by med_empowered on May 31, 2005, at 1:49:08
In reply to Re: Zyprexa Zydis, posted by Lynne on May 30, 2005, at 20:52:39
hey! I **hated** zyprexa; at 2.5mgs, I developed awful akathisia. I doubt the zydis tabs will be any better...basically, they're mostly used on people who can't...or, more often, *WON'T*...take the zyprexa. This way, as long as the tab gets in the mouth, that person takes the med. Its the same in terms of side-effects and weight gain and what not...it just dissolves. As for AMD...whenever you take any antipsychotic, it blocks off a good bit of the D2 transmission in your brain. Some of the atypicals, like zyprexa, also block off some serotonin receptors and may also hit up muscarinic (sp?) receptors and affect glutamate...since some of them have kind of long half-lives, it may take a while for all the drug-induced effects to go away, even if you only took the drug for a *brief* amount of time. There's also the possibility of withdrawal issues, but that's way more pronounced in those who have been taking the meds for a good while. For those who have taken high doses of the old antipsychotics, withdrawal effects can include psychosis, even if the person was taking the med for something unrelated to psychosis (old antipsycohtics have been used for anxiety, depression, "neurosis", senile agitation, behavior problems in children, adolescents, and the mentally handicapped, so on and forth.). This occurs because the dopamine blockade causes the development of brand new D2 receptors and makes all the D2 receptors hyper-sensitive; as the D2 blockade wears off and dopamine levels return to normal, a psychosis kind of like amphetamine psychosis can occur because the brain has become hyper-sensitive to dopamine.
poster:med_empowered
thread:505275
URL: http://www.dr-bob.org/babble/20050527/msgs/505617.html