Posted by SLS on May 29, 2005, at 16:24:15
In reply to Parnate not so good for melancholy, posted by Maxime on May 29, 2005, at 16:11:05
> Hi
>
> We have had some posts about how Nardil is more of a mood brightner than Parnate. I started to do some searching and it that Parnate isn't as effective for depression with melancholy. And they are right! That's exactly what it doesn't relieve for ME. I didn't know how to explain it but melancholy is perfect.
>
> I didn't find any document that explained why this is so, but I did find it cited in numerous places.
>
> I am glad I have a more specific way to describe how I feel or what part of the depression is "left over".
>
> Maxime
It is my belief that Nardil is more serotonergic than Parnate. I believe this makes a significant difference in its psychotropic effects. Serotonergics seem to be better "mood-brighteners" than noradrenergics. Noradrenergics might convey more energy - as does Parnate - but without serotonin, there is a lack of "feeling good" about things. Nardil also affects GABA systems. However, I could only guess as to whether this contributes to its anti-melancholic profile. It might prevent hyperactivity in the subgenual cingulate.
- Scott
poster:SLS
thread:504827
URL: http://www.dr-bob.org/babble/20050527/msgs/504830.html