Posted by sabre on May 17, 2005, at 2:09:37
In reply to Re: calcium channel blockers » sabre, posted by ed_uk on May 16, 2005, at 16:07:57
Hi Bill and Ed
Thanks for the replies.I have been busy changing jobs...again.
I have been limping along on Propranolol but I find I just end up feeling fatigued and depressed after taking it 3-4 X per week for work but I haven't found anything better.
After trialing Reboxetine, I found it great for around 4 days but then I ended crashing in a black hole. In the last week I have tried taking a small amount (.5g) 3 days apart and I found it acts like an upper.
I suspect the Prop. sucks the noradrenaline out of the system and the Rebox just replaces what's missing. Once the Rebox - NA gets to normal levels, any excess either causes a down regulation of the NA receptors or I get an overdose of NA... causing ugly depression at about day 3/4. Although I can't imagine downregulation occurring in 4 days??
I started researching beta blockers this week and found they do block NA reception. In addition, I assumed that if I took a beta blocker one day that by the next they would not affect exercise performance. Wrong. Apparently the beta blockage can extend to the next day (not at the same strength of course). I also discovered that exercise increases the level of bb in the plasma. I'm not sure if that means it intensifies the bb action though.
What beta blocker has the shortest half life?
I started looking at ACE inhibitors and calcium channel blockers as an alternative because sports med drs often prescribe them in preference to beta blockers for hypertension (not that I have hypertension) because they have less of an effect on aerobic power.
I found these articles:Calcium channel blockers for anxiety disorders?
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8986318Neuropsychiatric effects of cardiovascular drug therapy. (The calcium-channel blocker verapamil has been used as an adjunctive treatment in patients with bipolar disorders.)
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12620132Effects of verapamil and atenolol on exercise tolerance in 5,000 m cross-country running: a double-blind cross-over study in normal humans.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1696662Controlled study of verapamil for treatment of panic disorder.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2450479I was also thinking of trying Atenolol. According to this article, it doesn't affect aerobic power although I have read otherwise:
Hypertension in Athletes and Active Patients
http://www.physsportsmed.com/issues/1999/04_99/macknight.htm
Hope your studies are going well, Ed.sabre
poster:sabre
thread:498238
URL: http://www.dr-bob.org/babble/20050516/msgs/498801.html