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Re: Maximum Neurontin dose? » markhw2002

Posted by Larry Hoover on May 11, 2005, at 22:08:54

In reply to Re: Maximum Neurontin dose?, posted by markhw2002 on May 11, 2005, at 14:51:28

> Yes, I take 3600 of neuronitn--for social anxiety-- in two divided doses, and have been on this dosage for about two years. I have found, however, that it is beginning to lose its effectiveness and I am going to lobby my psych for a higer dose. I also take ativan prn and occasionally ambien (10mg) at night. Thanks.

I couldn't even imagine that dose. I'm struggling now at 600, and working down. I can't think of a better example of how differently people can react to the same drug.

Gabapentin has unusual bioavailability; as the dose increases, absorption percentage decreases, until at 4800 mg/day, uptake is only 27% (compared with 33% at 3600). That means that you get only a slight boost in total uptake from that large dose increase....less than 100 mg of the 1200 mg dose increase. (All figures based on averages from a number of subjects.)

You might get a better efficacy boost by taking it with food. That accounts for a 14% increase in uptake. Or, do both. Increase the dose, and always take it with food.

I'm thinking my dose will end up being in the 300-400 mg/day range.

Lar

 

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poster:Larry Hoover thread:390717
URL: http://www.dr-bob.org/babble/20050510/msgs/496680.html