Posted by Shawn. T. on May 11, 2005, at 19:09:54
In reply to is prozac an SSRI??, posted by woolav on May 11, 2005, at 5:55:16
I'm glad that you asked this question. In my opinion, Prozac should be called an SRI rather than an SSRI. This is because Prozac is not selective for the serotonin transporter. It acts as an antagonist at serotonin 5-HT2C receptors. A metabolite of Prozac, norfluoxetine, is a more selective and potent SRI than its parent compound (see http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10379421). The fact that most people still call Prozac an SSRI is an unfortunate habit because it obscures an important element of the drug's pharmacology.
Shawn
poster:Shawn. T.
thread:496309
URL: http://www.dr-bob.org/babble/20050510/msgs/496584.html