Posted by Larry Hoover on May 9, 2005, at 11:48:44
In reply to What happened to me in 1989?, posted by cubbybear on May 9, 2005, at 10:05:58
> I just realized that maybe someone on this board can figure out what went wrong when I had a horrific drug interaction way back. I had been taking a small dose of Elavil for chronic pain then popped a small amount of the powerful benzo (hypnotic) drug Halcion before bed to counteract insomnia. I woke up a few hours later, pacing the floors, feeling like I was having a bad drug trip, 5 minutes felt like an hour, it took me about 10 minutes to be able to walk a few paces to my neighbor's door to knock for help. This nightmare passed after about 4 hours.
> I'm curious to find out what went wrong here. Are benzos contraindicated with TCA antidepressants, or particularly with Elavil?
>I looked hard, and I can't find any pharmacokinetic interaction that would give you those symptoms. There is a very slight overlap in liver transformation of these drugs, but you seem to have had a paradoxical reaction.....the expected effect of the mild interaction I note would be increased sedation.
I wonder if you just happened to have a dream that led you to awaken....and you became aware of the sedative effect of the drug, without being able to go back to sleep. Your vigilant response might have kept alert, rather than letting yourself go. In other words, it wasn't the drugs, per se.....it was your psychological response to observing the drugs' effects.
Highly speculative, but I tried.
Lar
poster:Larry Hoover
thread:495520
URL: http://www.dr-bob.org/babble/20050504/msgs/495554.html