Posted by cache-monkey on May 8, 2005, at 14:47:13
In reply to Re: Darned dyslexic fingers, Depakote, GHB and sleep, posted by BIGDaddyachmed69 on May 8, 2005, at 9:41:24
<< As far as falling asleep, that's definately not the problem...I experience significant fatigue throughout the day. It's staying asleep...I wake up every couple hours if I don't take a Lunesta. So maybe that's the Depakote, I dunno... >>
Thanks for bringing up the dopamine rebound idea. That might explain some of my daily cycle in response to Depakote. I'm on the ER version and take my dose a couple of hours before bed. I tend to start feeling better and better around the time I take my dose, and that continues further for a while. I usually have trouble getting to sleep and staying asleep. I feel like I just sort of skim the surface of sleep the whole night. And wake up feeling like crap.
The thing about the ER version is that my Depakote levels should be falling around dosing time. But the ER version kicks in slowly with the peak after a single dose occuring 4-17 hours later.
If I'm at the longer end of that, I'd imagine my blood level to continue decline for a while after taking the dose. Upshot could be that I'm getting the dopamine rebound around the time that I'm trying to sleep.
Maybe I'll switch to the non-ER version and see if that makes a difference...
poster:cache-monkey
thread:494405
URL: http://www.dr-bob.org/babble/20050504/msgs/495228.html