Posted by KaraS on April 10, 2005, at 17:59:45
In reply to Re: *Serontonin Syndrome* - Ted and Ed » KaraS, posted by ed_uk on April 10, 2005, at 8:09:07
> Hi Kara,
>
> >Ed, those who have suffered life-threatening reactions, was it due to poor liver function or not breaking the meds down properly or is the reason just not known?
>
> I don't think the reason was known. I can only guess that some people do get significant inhibition of MAO-A at low doses. Due to the differences in drug metabolism between individuals, some people probably get unusually high serum concentrations from 10mg doses.
>
> Ed xx
I hate grey area. I guess it's a risk to try them together but not a huge risk. I wouldn't go above 5 mg. and with only a fairly low level of an SSRI or TCA. (Actually, I bet that trimipramine would probably be the safest as it is considered one of the safest TCAs to combine with other MAOIs.) And then just watch very carefully for signs of serotonin syndrome. Make sense?K
poster:KaraS
thread:481264
URL: http://www.dr-bob.org/babble/20050408/msgs/482490.html