Posted by Larry Hoover on March 27, 2005, at 8:26:29
In reply to Doing ok on clomipramine, posted by linkadge on March 26, 2005, at 20:20:38
> My moods are fairly good and I am sleeping well. The only think I can't shake is this headache and feeling of somebody pusing me.
>
> I'm only taking 25mg. I supposed to be on 100mg. I am a little concerned that more might make me too sedated. I will probably try to go to 50mg at least.
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> LinkadgeVery glad to hear from you, and to hear you're doing OK. :-)
Clomipramine (Anafranil) is an unusual drug. It has non-linear kinetics. Blood concentrations are not proportional to dose, and the individual plasma concentrations at a given dose cover nearly an order of magnitude, in clinical studies. Be careful with titrating your dose to the effect your receive. Targets (such as 100 mg) may be unreasonable, for you.
It is metabolized via four enzymes, two of which have shown substantial genetic variability (2C19 and 2D6). Your ability to metabolize this drug into its also active metabolites can be substantially different from other people.
What I'm saying is, be careful with the dose. Consider breaking pills, if you do an increase, to make the titration rate slower.
All the best,
Lar
poster:Larry Hoover
thread:475991
URL: http://www.dr-bob.org/babble/20050326/msgs/476170.html